DNA is baffling.
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General
Users
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In a nut shell...

How long will my results take?

Your results will be available within 2 weeks upon receiving your sample.

Who we are?

Rightangled is a UK based private company. Registered and regulated by the Care Quality Commission “CQC” in England as a healthcare provider for genetic testing. The company was backed and seed funded by NHS England during its early stage. Rightangled currently provides its genetic testing services through a unique online platform that connects patients with healthcare and wellness professionals. Rightangled's mission is to personalise healthcare, making precision medicine available and keeping medical knowledge accessible through an easy to use portal.

How does it work?

Choose the right test for you and order our saliva collection kit to your home. You can buy it through our website or collect it from one of our partner practitioners or retailers. Once you receive the kit, you will need to register it by creating an online account or by logging in to an existing one so that we know that the sample belongs to you. Once you are done, please send it back using the same pre-paid package.
Our partner lab will then do the genotyping and report the results back to us. Once we receive the results, we do the interpretation and analysis and pass the reports through quality review by a partner specialist, who will provide their assessment on your report before releasing the results to you.

What can I learn from my test?

Our Heart DNA test will help you to:
- Learn about your risks to develop certain cardiovascular conditions and how to reduce them.
- Understand how your body can respond to certain cardiovascular medications.
- Make personalised behavioural changes in your lifestyle and diet. Fitness DNA Test will help you to:
- Learn how your body responses to certain exercises.
- Learn about your risks associated with injury and obesity.
- Get personalised training and an 8 week dietary program.

Why did you start the company?

Rightangled was founded with the aim of making genetic testing accessible to everybody. After a personal experience of adverse drug side effects, co founders Abdullah and Floriane set out to prevent this from happening in the future by personalising patient care. Following profound results from the Heart DNA Test, we wanted to expand our product range to help more people live longer and healthier lives. This lead to the development of the Fitness DNA Test and Wellness Pro.

Can I opt out of some of the reports?

No, you currently cannot opt out of any reports. If you have any special requests please email [email protected] and we can offer further advice.

How do I talk to someone after receiving my report?

You can talk to our partner specialists using our concierge service by simply logging on to your online portal. We also have a dedicated support team here to answer any of your questions.

How is your product different to other ones on the market?

Other existing Direct to Consumer genetic testing companies are not providing the necessary medical consultation on the back of their reports, which is imperative in giving an accurate interpretation to the patient’s health (by taking into account the patient's medical history and other lifestyle and environmental factors).
We have built an integrated platform that enables doctors to provide their medical consultation online through secure and dedicated portals, so that our users can receive medically relevant assessment with personalised actionable plans.

How accurate is your test?

To ensure the efficacy of our data, we have partnered with ISO accredited labs that adhere to high standards of quality. Our gene panel list is assayed through a genotyping technology that utilises competitive allele-specific PCR, which enables highly accurate bi-allelic scoring of SNPs (99.8% accurate) and indels (insertions and deletions) at specific loci across a wide range of genomic DNA samples (SNP & indel assay conversion rate 90%), thereby limiting the risk of false-positive and false-negative results. Once this data is processed it is reviewed by our specialist partners, along with your provided health data, via our online portal in order to generate an accurate interpretation for each individual's results.

What studies are your tests based on?

The genetic markers used are based on large scale and ethnically diverse genome wide association studies (GWAS), meta-analysis studies, all databases in National Centre for Biotechnology Information (NCBI), Medical Subject Headings (MeSh) in Medline and the Short Genetic Variations database (dbSNP). Statistical values were a deciding factor in the study selection. P values, confidence intervals and odds ratio were all considered.

How many people can be tested with each DNA collection Kit?

One. Each DNA collection kit contains one tube allowing one person to provide a saliva sample and be analysed. If you wish to have more tests for other people, please get in touch with us for more details.

To you...

How can I review the reports of my patient?

Regarding our Heart DNA Test, our reports are reviewed by our cardiologist and GP partners. Being a partner is an easy process. After having signed our service agreement, we will set up an account for your cardiologist and any of your associated practitioners on our partners portal, where patients genetic results and self-reported data can be reviewed. We will then dispatch kits to your centre barcoded with unique kit IDs that will be assigned to the ordering practitioner. This will enable us to link the patient with their doctor.

Can I order to a non-UK address?

Yes, please specify your full address details on checkout and we will arrange for an international courier to deliver and return your sample collection kit.

Can I return my order and get a refund?

To be eligible for a return and refund, your item must be unused and in the same condition that you received it. It must also be in original packaging. Our refund policy lasts for 14 days.

Can I order more than one kit?

Yes, you can purchase as many kits as you wish. However, you can only register one kit per user.

What is the GDPR?

The General Data Protection Regulation (GDPR) has been in the works for a long time. Drawn up by the EU, it strengthens the data rights of EU residents and harmonises data protection law across all member states, making it identical. It increases the potential fines organisations face for misusing data, and makes it easier for people to discover what information organisations have on them. In essence, it seeks to bring more transparency to people about what data organisations collect about them, and what those organisations use it for, as well as enabling people to prevent unnecessary data collection.

Will my data be stored securely?

We are regulated by the Care Quality Commission "CQC" and registered with the Information Commissioner's Office "ICO". We are fully compliant with GDPR and all our data is encrypted.

Can I purchase DNA kit as a gift?

You can purchase a test for a relative or friend. They will need to register their kit online and fill out their health profile.

How do I reset my password?

Click the 'Forgotten your login details' link in the login page. Enter your account email address and we will send you password reset instructions.

How do I access my results?

After analysis and review, your results will be available through our website. You must log in into your account to access all your data.

How do I register my kit?

Once you have received your saliva collection kit, you will need to register its unique barcode number on our website by creating an account with valid email address/ or login to an existing one.

How do I place an order?

Orders can be placed on our website and we'll send the kit to you by mail. You can also collect it at one of our partners’ facilities.

Further info...

What comes with the purchase of the DNA kit?

We provide you with the substantial marketing collateral (info pack, brochures, poster, electronic marketing, Point Of Sale Stand) so you are able to communicate the value proposition.

I feel like I don’t know enough about pharmacogenomics and how the test works.

We provide you with white papers and literature if you would like an understanding of the science behind our tests.

Will I need to interpret my customers results?

No. A Health Care Professional will be assigned to the patient and will give their assessment in a way that is easy to understand. All the information explaining the reports are found online in our portal with links and references to further information if they want to know more. Furthermore, the patient has the option of booking a follow up appointment online with our partnered HCP if they have any questions related to their report.

How will stocking this kit benefit my pharmacy?

Pharmacy is a changing landscape where there is now more emphasis on providing services rather than purely dispensing prescriptions. Part of this reason is due the decreasing margin to be made in dispensary. Stocking our kit provides you with an attractive margin in the current climate and enables you to have a deeper level of conversation with your patients, increasing patient satisfaction and loyalty. Research by Price Waterhouse Cooper reveals that an increasing number of consumers are willing to pay for aspects of their treatment such as diagnostic and basic tests and interventions if they get value for money alongside convenience and access. Additionally, pharmacogenomics is the future of medication management and prescribing, and by offering this you will give your pharmacy a competitive edge and a point of difference, as well as be a frontier with this technology.

Where does this fit into services I provide in my pharmacy?

Heart DNA
Offer our Heart DNA Test as part of health checks, Medication Usage Reviews or other in-house screening services.

Fitness DNA
This kit can be sold as an adjunct to weight loss services you may provide or as part of a health check.

What are the storage conditions and shelf life?

The kits are compact (20cm x 15cm x 2.2 cm) and has no specific storage conditions. It has a long shelf life of 5 years.

How does the Heart DNA test differ from a regular health check customers can get from their doctor?

Our test looks at genetic markers which are linked with a higher risk to develop certain cardiovascular conditions as well as asking about family history and lifestyle. Patients are informed of risks before they are symptomatic and are empowered with knowledge and an action plan to minimise those risks. Current health checks measure blood glucose, blood pressure and blood cholesterol. Patients are often made aware of their increased cardiovascular risk when they are already showing symptoms.

Which customers should I sell this to?

Heart DNA
-Patients with pre-existing cardiovascular conditions and are unstabilised on medications or are about to initiate medication.
-Individuals who have a family history of cardiovascular disease
-Health enthusiasts who would like to be more informed of their risks Fitness DNA
-Individuals who want to improve their fitness level and nutritional status
-Individuals who want to understand their eating behaviours and lose weight -Individuals who want to understand how their body responds to certain exercises, eating habits and nutrients, including blood sugar. -Individuals who want to learn about their risks associated with injury and obesity.

Further info...

Is the test covered by insurance?

Our inherited thrombophilia testing is covered by Bupa. This diagnostic test enables you to predict an increased risk of venous thrombosis by testing for factor V Leiden, prothrombin G20210A. It also tests the risk of arterial thrombosis by testing homocysteine and folate metabolism, through testing of MTHFR gene as well. If you would like to refer patients to us, please feel free to use the online website form here.

Where is the evidence base behind your test?

Heart DNA test covers 24 genetic reports that are based on qualified and accepted research, the scientific evidence is based on Genome Wide Association Studies (GWAS) and on large scale Meta-analysis studies. In addition, all markers and interpretations in our pharmacogenetic tests are based on internationally accepted and recognised guidelines, such as those adopted by the FDA and found on the prescription guidelines for drugs such as Clopidogrel and Warfarin. Moreover, all our reports and interpretations have been reviewed by genetic counsellors from Guy’s and St Thomas' Hospital.

How do you enhance the patient experience?

A positive patient experience is an important goal in its own right including patient adherence to medical advice, better clinical outcomes, improved patient safety practices, and lower utilisation of unnecessary health care services. The evidence on using precision medicine in drug prescription have highlighted increased patient satisfaction and improved drug compliance due to increased confidence by patients in their prescribed treatment. Our test would also help the practice to retain existing patients and improve patient loyalty, as well as attract new patients by offering a competitive advantage represented by our personalised medicine approach. We provide better CVD prevention management => genetic data determines if individuals would benefit from early interventions to prevent the development of CVDs. We provide a better CVD risk management => prescribing drugs with fewer side effects, increasing patient compliance, and reducing rehospitalisation rates could help reduce costs. Currently, an individual’s risk of developing CVD can be assessed by their lifestyle factors, such as physical activity levels, diet and smoking; but this doesn’t consider the genetic susceptibility to CVDs. When an individual is classed as an intermediate risk based on these lifestyle factors, it can be hard to determine if they will progress into developing CVDs, which is where genotyping could become extremely useful. Genotyping determines the risk of CVD, but results also determine the most effective medication which could be prescribed, reducing prescriptions of medication that is ineffective or causes adverse side effects.
In the case of warfarin, which is responsible for many adverse side effects, genotyping of patients has been shown to reduce rehospitalisation rates .

How can I refer patients to you for the thrombophilia testing?

The inherited thrombophilia screening covered by Bupa, tests for prothrombin 20210 mutation, factor V, and MTHFR genes, which may provide a better informed consent when initiating a patient on Oestrogen Supplementation or for testing of Venous Thrombosis and folate deficiency.
If you would like to refer patients to us, please feel free to use the online website form here.

How will your solution improve my practice ?

The evidence on using precision medicine in drug prescription has highhlighted increased patient satisfaction and improved drug compliance due to increased confidence of patients in their prescribed treatment. Our test would also help the practice to retain existing patients and improve patient loyalty, as well as attract new patients by offering a competitive advantage represented by our personalised medicine approach. The thrombophilia screening is covered by Bupa. This test determines the patient's genetic profile for Prothrombin 20210, Factor V Leiden and MTHFR genes and evaluates the predisposition to thromboembolism. Heritable thrombophilia is an inherited tendency for venous thrombosis and as you know most people with thrombophilia don't show any symptoms.

How does the test change my clinical decision making?

We do not change your clinical decision making, we support you for a more objective risk assessment combining the patient genetic risk profile and environmental risk factors. We offer your patient access to the full information regarding to the gene tested, the condition, the drug and all the resources used to write the report for a full understanding. Also, patients can book an appointment or a phone call with our partner doctor to follow-up on his/her results

How do you protect patient data?

We only keep data for as long as we need to in order to provide ourservice and/or for as long as we have the patients permission to keep it. Patients data will only be stored within the European Economic Area ("the EEA"). Anonymised data/patient characteristics are kept to assure quality control, improvements and research.
Data security is of great importance to us, and to protect patients data we have put in place suitable physical, electronic and managerial procedures to safeguard and secure data collected through our site. Steps we take to secure and protect patients data include but are not limited to: data held in a secured database server, protected by a dedicated firewall. All data transfers are secured over 2048 bit SSL in the UK. Notwithstanding the security measures that we take, it is important to remember that the transmission of data via the internet may not be completely secure and you are advised to take suitable precautions when transmitting data to us via the Internet.

How is the test accurate?

Where are you selling the kit at the moment?

We are currently working with pharmacies, private clinics and partner distributors.

Where can I access the reports of my patients?

After having signed our service agreement, we will set up an account for your cardiologist and any of your associated practitioners on our partners portal, where patients genetic results and self-reported data can be reviewed. We will then dispatch kits to your centre barcoded with unique kit IDs that would be assigned to the ordering practitioner. This will enable us to link the patient with their doctor.

Where are your analyses made?

IDna Genetics Ltd.
CENTRUM
Zone 2
Norwich Research Park
Colney Lane
Norwich
NR4 7UG
United Kingdom

What are your certifications and regulations evidence?

Rightangled is a healthcare provider for screening and diagnostic procedures, registered and regulated by the Care Quality Commission “CQC”. Our service has been backed and funded by NHS England. All our partner labs are ISO 15189 accredited and ours follow service agreements that ensures our turn around time is within a 2 week frame.

What type of analysis are you using?

SNP Genotyping With Real-Time PCR.
Your sample will be analysed and assayed through a genotyping technology that utilises competitive allele-specific PCR, which enables highly accurate bi-allelic scoring of SNPs (99.8% accurate) and indels (insertions and deletions) at specific loci across a wide range of genomic DNA samples (snp & indel assay conversion rate 90%). Thereby limiting the risk of false-positive and false-negative results. In our Heart DNA Test we analyse 96 markers that are associated with cardiac conditions, drug responses, lipid metabolism and thrombophilia.

What is the value for my patients ?

Patient experience through personalised care, better informed consent, cutting edge technology and patient centered cutting edge technology.

Can I do only the test that I want within all the reports that you propose?

You are free to choose among the cardiac screening, the pharmacogenetic testing, the lipids metabolism analysis or the inherited thrombophilia testing. You can also choose the full Heart DNA Test package.

What do you add to my current practice?

Incorporate a new approach to personalised care through a validated and evidence based genetic testing.
We support your clinical decision by offering to your practice a more objective risk assessment for CVD and VTE and a more accurate management of patients treatment.

What is the value of the test in the primary care setting ?

The emphasis in primary prevention should be shifted from high-risk prevention to prevention at any level of CVD risk, with the focus on behavioural risk factors. We offer to your practice a more objective risk assessment for CVDs in the aim to reduce it.
Also, we offer the possibility to optimise patient treatment aiming to reduce side effects and find the most efficient drug.

When do I need to refer patients to you for thrombophilia testing ?

Inherited thrombophilia testing can be used for asymptomatic patients with family history, or for a symptomatic patient for DVT or PE or when a high risk of thrombosis is increased, for example during pregnancy, through oestrogen therapy from combined oral contraceptives or hormone replacement therapy, risk of obesity, fractures and major orthopaedic surgery. This test is covered by Bupa and available for all eligible patients.

How much time do I need to wait before I get my results ?

Once the saliva sample is sent back, the lab proceeds to the analysis and you will get the results in 2 to 4 weeks.

When I will receive the kit after ordering ?

After ordering, you will receive your kits by post in 2 to 3 business days.

At which step of my practice is the test helpful ?

- As a prevention test to assess the risk of CVD. You can propose Heart DNA test during a risk assessment consultation.
- As an adjunct to optimise treatment for patients already on medications.

Which medical team are you working with ?

Rightangled operates out of its HQ at Scrutton Street in London, and has a branch office in Austin, the United states. The company’s board of directors is led by some of the leading cardiologists at St. George’s, University of London and the Barts Heart Centre in London as well as world renowned medical consultants from UCL Medical school, the Royal Free and Guys & St. Thomas Hospitals.

Can I review the Heart DNA Test reports as a GP ?

We are currently working with GPs to review patient reportS through our online platform. Via this platform, you will have access to the health profile of your patient (which is the same set of question as QRisk and JBS3) and in addition, the genetic predisposition. We support all our partners with all educational materials to teach them how to review reports.

Which patients will benefit most from the Heart DNA Test?

Our cardiac screening test would be mostly beneficial for patients with a family history of CVD and where anxiety is a key factor. It would also be very useful for patients with existing cardiac conditions and would like to learn more about their conditions and their genetic risk profile of how they developed such conditions. And of course anyone who would like to have a screening test to know more about their heart health and to undertake further physical examinations whenever a high risk is identified. This drug response test is best suited for patients with existing conditions and/or for patients who are about to start medicating, and the practitioner would like to optimise their treatment through personalisation and precisely identify their response to certain drugs beforehand.
Inherited thrombophilia testing can be use for asymptomatic patients with family history or when a high risk of thrombosis is increased, for example for pregnancy, oestrogen therapy from combined oral contraceptives or hormone replacement therapy, obesity, fractures and major orthopaedic surgery.