April 1, 2018

Cardiac Conditions

Your Genetic Inheritance

The British Heart Foundation estimates that Cardiovascular (heart and circulatory) disease causes more than a quarter (26%) of all deaths in the UK; that’s over 150,000 deaths each year – an average of 420 people each day or one death every three minutes. 

Cardiovascular diseases (CVD) can be genetically inherited. There is a chance you might be a carrier. Early identification is key in preventing the onset of heart disorders. Testing for these genes can help you begin the correct interventions to reduce your risk of developing heart disease. It can also give important answers and insights on how to manage CVDs to those already diagnosed with a cardiac condition.


Screen for CVD related genes and put a prevention plan in place.

Cardiac arrest, Atrial Fibrillation, Hypertension, Pulmonary Arterial Disease (PAD), Heart Attack and Coronary Artery Disease are some of the most common medical events that someone may have. Learning if you are a carrier for a genetic risk mutation can help you in a magnitude of ways. With this test, you can:

Learn about the genetic basis of an existing condition. Discover if you have any genetic traits predisposing you to develop cardiac conditions.
Prevent prognosis by starting an actionable plan with our partner Doctor. Cascade test other family members and begin an early intervention plan; Slowing CVD progress in other family members who might carry the same gene.


Conditions we test for

APOE, TYPE III Hyperlipoproteinemia

A rare genetically inherited disorder resulting in the improper function of APOE, a protein involved in transporting and clearing fats and cholesterol. Mutations in this gene results in the build-up of fatty materials in blood vessels, obstructing blood flow and resulting in coronary heart disease. This test would determine your genotype and the risk of developing Type III HLP.

Gene Tested: APOE

Atrial Fibrillation

A common form of abnormal heart rhythm, a major cause of stroke and association with coronary heart disease. In a normal condition, the heart's pacemaker sends regular electrical impulses. However, in AF, these impulses are sent out in a disorganised manner resulting in an irregular and fast pulse. This test would determine your genotype and risk of developing of Atrial Fibrillation.

Gene Tested: PITX2

Coronary Artery Disease

This disease involves the narrowing of the coronary arteries, the main supply line of oxygenated blood to the heart. This narrowing is caused by a build-up of plaque along the walls of the artery. The cause of CAD is strongly influenced by a patient's genetics and his/her lifestyle. This test would determine your risk of developing coronary heart disease.

Genes Tested: CDH13, HNF1A, MRAS, MTHFD1L, SEZ6L, SMAD3, CXCL12, MIA3, OR13GI, APC, CDKN2B and LPL


Blood pressure is required to deliver blood to all areas of the body. Hypertension is when the pressure is above normal and can result in the enlargement of the heart leading to heart failure. This test would determine your genotype and the risk of developing hypertension.

Genes Tested: BCAT1 and PPARGC1A

Myocardial Infarction

This life-threatening event occurs when the blood supply to the heart is blocked usually by a blood clot in the coronary arteries. This test would determine your genotype and the associated risk of a myocardial infarction occurring.

Genes Tested: CXCL12, MIA3, OR13G1, PCSK9, PHACTR1, PRR4, SH2B3, WDR12 and Intergenic SNPs

Peripheral Arterial Disease

The narrowing of the arteries which supply blood to leg muscles. These arteries become narrowed due to the gradual build-up of fat within the artery walls. Loss of blood to leg muscles can cause pain and discomfort when walking. This test would determine your genotype and risk of developing peripheral arterial disease.

Gene Tested: CHRNA3

Venous Thrombosis

A blood clot that forms within a vein. A Venous Thrombosis can be classified based on its location and severity. If however, a thrombus (blood clot) breaks off and travels towards the lung blocking an artery, pulmonary embolism can develop, a severe life-threatening condition. This test would determine your genotype and risk of developing venous thrombosis.

Genes Tested: MTHFR, Prothrombin and Factor V Leiden

Sickle Cell Anaemia

An inherited condition that is characterised by abnormally shaped red blood cells. These cells are incapable of surviving as long as healthy cells, thus they are destroyed and anaemia develops (lack of red blood cells). Individuals who possess one sickle cell gene and one normal gene are known to have the "sickle cell trait" (SCT). These individuals may not necessarily present any symptoms; however, they are able to pass on the gene. Individuals carrying both genes develop Sickle Cell Anaemia. This test will determine if and how many sickle cell genes you possess.

Gene Tested: HBB


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