March 26, 2018

Diet & Nutrition

Your metabolism and your cardiac health


A healthy diet reduces the risk of developing chronic diseases and improves your overall health.

Your genetic makeup can determine how you metabolize certain nutrients and directly influence your health and cardiac fitness. Genes do not act alone. The action of one gene may depend on other genes but also on your environment, current diet and exercise.

This genetic test report combines these factors to let you understand how your body responds to nutrients. Allowing you to tailor your lifestyle and diet to reduce the risk of developing cardiovascular diseases.

 


Learn how you can reduce your risks of disease and improve your health through diet changes

Comprehensive nutritional requirements need consideration of the underlying genetics. These may surface as differences in metabolic processes like absorption, metabolism, and excretion. In this test you will:

Learn how your body metabolizes nutrients that have a direct influence on your heart and health. Learn how to change your lifestyle to reduce your risk of developing cardiovascular diseases.

 

Metabolic Components in the Test


Caffeine Metabolism

Caffeine is a natural drug found in coffee beans, tea and carbonated drinks. It is useful in relieving the effects of drowsiness and increasing alertness. Caffeine has the ability to bind to receptors (proteins) on the heart causing increased heart rate. Although in small doses this can be good, large doses can cause uncontrollable heart rate. This test would govern your genetic makeup or genotype and more specifically the rate in which your body degrades caffeine.

Gene Tested: CYP1A2

Folate

Also known as Folic acid, is a B vitamin required by the body to make DNA. Folate cannot be created by the body and is therefore required in the diet through numerous food sources. If you have insufficient levels of folate, this can lead to folate deficiency. Folate deficiency is linked with decreased levels of folate and increased levels of homocysteine, the substance linked to the increased risk of cardiovascular diseases. This test will determine your folate and homocysteine levels, therefore indicating the risk of cardiovascular diseases.

Gene Tested: MTHFR

Triglycerides

Triglyceride is a component of body fat and is present in the blood, important for transporting body fat to the liver. High levels of triglyceride is associated with increased risk of heart disease. This test will determine your triglyceride levels and your risk of developing heart disease.

Genes Tested: ANGPTL3, APOB, FADS1, GCKR, LPL, MLXIPL, NCAN, PLTP, TRIB1, XKR6, ZNF259

HDL Cholesterol

High-density lipoprotein (HDL) also known as "good" cholesterol removes excess and bad cholesterol from the bloodstream rather than depositing it in the arteries. Cholesterol accumulation in the arteries can lead to Atherosclerosis, leading to plaque ruptures and clotting, which in turn, may cause cardiovascular complications. Decreased levels of HDL poses an increased risk of developing cardiovascular problems therefore this test would determine your HDL levels and the risk of developing cardiovascular diseases.

Genes Tested: ABCA1, ANGPTL4, CETP, FADS1, GALNT2, HNF4A, KCTD10, LCAT, LIPC, LIPG, LPL, PLTP, TTC39B, ZNF259

LDL Cholesterol

Low-density Lipoprotein (LDL) also known as "bad" cholesterol transport cholesterol to the arteries allowing the build-up of plaque resulting in the narrowing of blood vessels. As a result this leads to cardiovascular problems such as high blood pressure. High levels of LDL therefore increases the risk of developing cardiovascular diseases and this test would determine your LDL levels and the associated risk.

Genes Tested: LDLR, MAFB, NCAN, PCSK9, ABCG8, APOB, CELSR2, HMGCR, HNF1A and Intergenic SNPs

Gene X (ASGR1 Variant)

A recent gene discovered in 2016, called Gene X, has protective effects towards cardiac health. Carriers of Gene X have a 34% reduction in their risk of coronary artery disease along with additional health benefits including low and high levels of LDL and HDL respectively. This test would determine if you possess a copy of this gene and its associated health benefits.

Gene Tested: ASGR1

 

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