April 1, 2018

Drug Response

Your heart medication and you


 

The world of medicine is full of drugs, however, many may not work for you.

The modern one-size-fits-all method of drug prescriptions may leave you with unwanted side effects and regular medication changes until you find any therapeutic benefit. The World Health Organization estimates 50% of patients eschew prescribed medications for fear of side effects, communication barriers, information technology, and healthcare access. Our test removes these barriers. Helping you reach an ideal treatment.

 


Genetics can help your practitioner direct your course of treatment.

This test can help your practitioner direct your course of treatment by identifying the drugs that will benefit you the most, reducing the trial and error, and avoiding unnecessary side effects. Anyone beginning or currently being treated for heart disease could certainly benefit from more information. This genetic report will allow you to:

Understand how your body responds to drugs and their effectiveness. Identify which medication would best fit your unique genetic makeup.
Determine ideal dosages to start taking certain drugs. Avoid the trial and error of drug prescriptions and unwanted side-effects.

 

Drug Responses in the Test


Beta Blockers

A class of drugs used in the treatment of angina, heart failure, atrial fibrillation and high blood pressure. Beta blockers work by lowering blood pressure and flow to heart, thereby reducing stress and pressure on the heart. This test would determine your genotype and the type of response you would have when using beta-blocker treatments.

Gene Tested: GRK5

Beta Blockers and LVEF Response

Left Ventricular Ejection Fraction (LVEF), is used as a measurement to detect heart failure. It is the amount of oxygenated blood pumped around the body, therefore an indication of heart efficiency. This test would determine your genotype and associated efficiency response following beta-blocker treatment.

Gene Tested: ADRB1

Warfarin

An anticoagulant drug also referred to as "blood thinner" is used to prevent harmful blood clots from forming. This test would determine your genotype and the dosage of Warfarin you require.

Genes Tested: CYP2C9 and VKORC1

Clopidogrel Metabolism

An antiplatelet drug used to reduce the risk of heart disease and stroke. The drug works by preventing platelets from binding together that would otherwise lead to the formation of blood clots. This test would determine your genotype and your ability to metabolise Clopidogrel.

Gene Tested: CYP2C19

Verapamil and QTC Interval

A drug used to treat hypertension (high blood pressure), angina (chest pain) and arrhythmias (irregular beating). Calcium causes blood vessels to tighten, therefore increasing blood pressure. Verapamil blocks calcium entry, causing the vessels to widen and lower blood pressure. Changes within a calcium gene can cause adverse effects when on Verapamil treatment. This test would determine your genotype and the risk of developing cardiac problems whilst on Verapamil treatment.

Gene Tested: NOS1AP

Verapamil vs. Atenolol

Two classes of drugs (beta-blockers and calcium channel blockers) are used to treat heart diseases and high blood pressure. Verapamil is a calcium channel blocker and Atenolol is a beta-blocker. In some cases, our genes control how effective we respond to one treatment over the other. Our genes determine which drug we would respond better to. This test would determine which drug you are most likely to benefit from.

Gene Tested: CACNA1C

Simvastatin Induced Myopathy

A form of drugs called statin, are used to reduce the amount of cholesterol in your blood. A common side effect of statin use is Myopathy (muscle disease). This test would determine your risk of developing Myopathy due to statin use.

Gene Tested: SLCO1B1

Metoprolol Metabolism

A type of beta-blocker used to treat angina and hypertension. An enzyme found in the liver is responsible for breaking down 60% of Metoprolol. This test would therefore determine your enzyme levels and ultimately the recommended dose of Metoprolol to be given.

Gene Tested: CYP2D6

Perindopril

Perindopril is a long acting enzyme inhibitor (ACE inhibitor), used to treat hypertension. Changes in the gene of this enzyme increase the chances of severe side effects whilst taking perindopril. This test would determine your genotype and risk of any cardiac events while using Perindopril.

Genes Tested: AGTR1 and BDKRB1

Estrogen Supplementation

Drugs containing estrogen such as those found in hormone replacement therapy and oral contraceptive pills are known to increase the risk of developing clotting disorders and thrombosis. This test would determine your genotype, as well as any genetic predispositions causing thrombosis when taking drugs containing estrogen.

Genes Tested: Factor V Leiden and F2 Prothrombin

 

Order this test References