You and your inherited genes

According to the British Heart Foundation, over 620,000 people in the UK are carrying a faulty gene that puts them at high risk of developing coronary heart disease or an inherited heart condition.

If you have a family history of cardiovasular diseases (CVD), the cause might be geneticaly inherited and there is a chance you might be a carrier.

Early identification is key in preventing the onset of heart disorders. Testing for these genes can help you implement the correct interventions that can reduce your chances of developing a heart disease.

Also, if you have been recently diagnosed with a cardiac condition, this test can help you get some answers.

Screen for CVD related genes and put a prevention plan in place

Cardiac arrest, Atrial Fibrillation, Hypertension, Pulmonary Arterial Disease (PAD), Heart Attack and Coronary Artery Disease are some of the most common events that anyone may have at any stage in their lives.

Learning if you are a carrier for an inherited condition can help you and your family take the necessary steps to plan and prepare for the future. With this test, you can:

Learn about the genetic basis of an existing condition.

Find out if you have any associated genetic predispositions that might be affecting your susceptibility of developing cardiac conditions.

Put an actionable plan in place with our partner medical practitioner to prevent these conditions from happening.

Through early interventions, impede CVD prognosis in other family members who might be carrying the same gene.

Conditions we test for

This genetic test will cover the following cardiac conditions:

  • APOE, TYPE III Hyperlipoproteinemia

    A rare genetically inherited disorder resulting in the improper function of APOE, a protein involved in transporting and clearing fats and cholesterol. Mutations in this gene results in the build-up of fatty materials in blood vessels, obstructing blood flow and resulting in coronary heart disease. This test would determine your genotype and the risk of developing Type III HLP.

    Gene Tested: APOE

  • Atrial Fibrillation

    A common form of abnormal heart rhythm, a major cause of stroke and association with coronary heart disease. In a normal condition, the heartís pacemaker sends regular electrical impulses. However, in AF, these impulses are sent out in a disorganised manner resulting in an irregular and fast pulse. This test would determine your genotype and risk of developing of Atrial Fibrillation.

    Gene Tested: PITX2

  • Coronary Artery Disease

    This disease involves the narrowing of the coronary arteries, the main supply line of oxygenated blood to the heart. This narrowing is caused by a build-up of plaque along the walls of the artery. The cause of CAD is strongly influenced by a patientís genetics and his/her lifestyle. This test would determine your risk of developing coronary heart disease.

    Genes Tested: CDH13, HNF1A, MRAS, MTHFD1L, SEZ6L, SMAD3, CXCL12, MIA3, OR13GI, APC, CDKN2B and LPL

  • Hypertension

    Blood pressure is required to deliver blood to all areas of the body. Hypertension is when the pressure is above normal and can result in the enlargement of the heart leading to heart failure. This test would determine your genotype and the risk of developing hypertension.

    Genes Tested: BCAT1 and PPARGC1A

  • Myocardial Infarction

    This life-threatening event occurs when the blood supply to the heart is blocked usually by a blood clot in the coronary arteries. This test would determine your genotype and the associated risk of a myocardial infarction occurring.

    Genes Tested: CXCL12, MIA3, OR13G1, PCSK9, PHACTR1, PRR4, SH2B3, WDR12 and Intergenic SNPs

  • Peripheral Arterial Disease

    The narrowing of the arteries which supply blood to leg muscles. These arteries become narrowed due to the gradual build-up of fat within the artery walls. Loss of blood to leg muscles can cause pain and discomfort when walking. This test would determine your genotype and risk of developing peripheral arterial disease.

    Gene Tested: CHRNA3

  • Venous Thrombosis

    A blood clot that forms within a vein. A Venous Thrombosis can be classified based on its location and severity. If however, a thrombus (blood clot) breaks off and travels towards the lung blocking an artery, pulmonary embolism can develop, a severe life-threatening condition. This test would determine your genotype and risk of developing venous thrombosis.

    Genes Tested: MTHFR, Prothrombin and Factor V Leiden

  • Sickle Cell Anaemia

    An inherited condition that is characterised by abnormally shaped red blood cells. These cells are incapable of surviving as long as healthy cells, thus they are destroyed and anaemia develops (lack of red blood cells). Individuals who possess one sickle cell gene and one normal gene are known to have the Ďsickle cell traití (SCT). These individuals may not necessarily present any symptoms; however, they are able to pass on the gene. Individuals carrying both genes develop Sickle Cell Anaemia. This test will determine if and how many sickle cell genes you possess.

    Gene Tested: HBB

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