Available to US patients only. Zepbound is FDA approved and dispensed from our licensed New York pharmacy. It is not currently authorised for sale in the UK, EU, or any market outside the United States.

Zepbound is a once weekly injection for chronic weight management in adults. It contains tirzepatide, the same active ingredient as Mounjaro, which is sold as Mounjaro in the UK and EU. Both are made by Eli Lilly and work in exactly the same way: by activating two natural appetite hormones (GLP-1 and GIP) at once. In clinical trials, patients on the highest 15mg dose lost an average of 22.5% of their body weight over 72 weeks alongside a reduced calorie diet and more physical activity.

Are you eligible?
Zepbound is FDA approved for adults with a BMI of 30 or above, or 27 and above if you also have a weight related condition such as type 2 diabetes, raised blood pressure, high cholesterol, or obstructive sleep apnea. It's also approved specifically for treating moderate to severe obstructive sleep apnea in adults with obesity. Treatment must be combined with a reduced calorie diet and increased physical activity to get the best results. Our US licensed clinicians review your eligibility as part of your consultation.

How it works
Tirzepatide mimics two naturally occurring gut hormones, GLP-1 and GIP. Together they reduce your appetite, slow how quickly your stomach empties, and help you feel satisfied for longer after eating. The dual action is what sets tirzepatide apart from single hormone medications like semaglutide (Wegovy), and it's part of the reason Zepbound has produced the largest average weight loss of any approved obesity medication in clinical trials.

What the clinical evidence shows
The SURMOUNT trial programme studied tirzepatide across thousands of participants. On the 15mg maintenance dose, patients lost an average of 22.5% of their body weight over 72 weeks. More than nine in ten participants lost at least 5% of their starting weight, and over half lost 20% or more. Many also saw improvements in blood pressure, cholesterol, and sleep apnea symptoms.

Your treatment with Rightangled
Zepbound is dispensed from our licensed New York pharmacy in compliance with all federal and state pharmaceutical regulations. Every prescription is reviewed by a US licensed clinician, not by an algorithm. Most assessments are reviewed the same day. Your medication arrives in discreet, temperature controlled packaging, and our clinical team is available throughout your treatment if anything comes up.

What's in the box
This pack contains four pre filled single dose pens, which is one month of treatment. The injection needles are built into each pen, so there's nothing to attach. The official Medication Guide and access to our clinical support team are also included.

Your dosing schedule
Treatment starts low and increases gradually so your body has time to adjust. You'll begin on 2.5mg once a week for the first four weeks, then move up to 5mg, 7.5mg, 10mg, 12.5mg, and finally 15mg as your ongoing maintenance dose from week 21 onwards. Each step lasts around four weeks. Your clinician may slow this down if you're experiencing side effects, or hold you on a lower dose if it's working well for you. Many patients reach their goals comfortably on 10mg or 12.5mg without needing to go higher.

What to expect from side effects
The most common side effects are digestive: nausea, mild diarrhea, constipation, and occasional vomiting. They're usually mild, tend to settle within a few weeks, and are most noticeable just after a dose increase. Eating smaller meals more often and easing off rich, fatty foods makes a real difference for most patients.

When Zepbound isn't suitable
Zepbound isn't right for everyone. You shouldn't take it if you or a close family member has a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, or if you've had a serious allergic reaction to tirzepatide. It also isn't safe during pregnancy, while trying for a baby, or while breastfeeding. You should stop treatment at least two months before trying to conceive. Tell our clinicians during your consultation if you have a history of pancreatitis, gallbladder disease, kidney disease, diabetic eye disease, or take other diabetes medications.

Getting started
Start with our short online consultation. It takes around five minutes and asks about your health, medical history, and weight loss goals. One of our clinicians reviews your answers, usually within hours, and if Zepbound is suitable for you we'll dispense your prescription and ship it from our New York pharmacy.

Zepbound or Wegovy tablets?
Both are FDA approved for weight management, but they're different medications. Zepbound contains tirzepatide and works on two appetite hormones (GLP-1 and GIP), with an average weight loss of 22.5% in trials. Wegovy tablets contain semaglutide and work on GLP-1 alone, with an average weight loss of 13.6%. Zepbound is a once weekly injection that needs refrigeration; Wegovy tablets are taken daily on an empty stomach without refrigeration. Your clinician will help you decide which is the better fit for your goals, medical history, and lifestyle.

Zepbound is a prescription only medicine. It carries a boxed warning regarding the risk of thyroid C-cell tumors and must be prescribed after a proper medical assessment. For full prescribing information, please refer to the FDA approved Prescribing Information.

Important: This product is available only to patients located in the United States. It cannot be ordered or shipped to the UK, EU, or any other market. UK and EU patients seeking the same active ingredient (tirzepatide) can find Mounjaro through Rightangled UK. Zepbound® and Mounjaro® are registered trademarks of Eli Lilly and Company. Rightangled is not affiliated with or endorsed by Eli Lilly and Company.