We understand the anxiety around cardiovascular diseases.
The Heart DNA Test can identify the genetic risk of developing cardiac conditions, drug response and abnormal cholesterol levels.
Learn how your genetics and lifestyle predisposes you to certain cardiac conditions and prompts the display of drug side-effects.
Gain a deeper insight into the genetic factors of an existing condition or a drug interaction. Our content rich reports are informative and easy to follow.
Identify a treatment regimen that works for you or tailor an early intervention programme to optimise your health. Our doctors' reviews are comprehensive and profound.
Protect your cardiovascular system from unwarranted episodes, cut through trial and error of drug prescriptions and avoid side-effects.
Heart DNA reports will give you deeper insights into cardiac conditions, drug responses and dietary metabolism. Click on any of the tests below to read more.
We screen for genetic predispositions linked to cardiovascular diseases and identify any associated risks that might be affecting your cardiac health and wellness.
+ TYPE III Hyperlipoproteinemia
A rare genetically inherited condition characterised by improper breakdown of lipids, causing build-up of fatty materials in blood vessels. This blocks blood flow and can cause coronary heart disease or peripheral vascular disease. This test determines your risk of developing this condition.
Gene Tested: APOE
+ Atrial Fibrillation
A heart condition characterised by irregular and abnormally fast heart rate. This can cause dizziness, shortness of breath and tiredness, but symptoms don’t always manifest. Atrial fibrillation is a major cause of stroke and coronary heart disease.
Gene Tested: PITX2
+ Coronary Artery Disease
In this condition, the heart’s blood supply is blocked by a build-up of fatty materials along the walls of the coronary arteries and can lead to atherosclerosis overtime. Symptoms of the disease aren’t always noticeable. The cause of CAD is strongly influenced by your genetics and lifestyle.
Gene Tested: CDH13, HNF1A, MRAS, MTHFD1L, SEZ6L, SMAD3, CXCL12, MIA3, OR13GI, APC, CDKN2B and LPL
1 in 4 adults in the UK have high blood pressure (above 140/90 mmHg). Symptoms of this condition aren’t always noticeable. If left untreated, high blood pressure puts extra strain on your blood vessels, heart and other organs, and can increase your risk of life-threatening conditions such as heart attacks and strokes.
Genes Tested: BCAT1 and PPARGC1A
+ Myocardial Infarction (Heart Attack)
A life-threatening event that occurs when the blood supply to the heart is blocked, usually by a blood clot in the coronary arteries.
Genes Tested: CXCL12, MIA3, OR13G1, PCSK9, PHACTR1, PRR4, SH2B3, WDR12 and Intergenic SNPs
+ Peripheral Arterial Disease
Arteries that supply blood to leg muscles become narrowed due to the gradual build-up of fat within the artery walls. Reduced blood flow to leg muscles can cause pain and discomfort when walking. This test would determine your risk of developing this disease.
Gene Tested: CHRNA3
+ Sickle Cell Anaemia
An inherited condition where the red blood cells are unusually shaped and can cause problems as they do not survive as long as healthy blood cells. This disease is caused by a faulty gene that affects how red blood cells can develop. Individuals with one sickle cell gene and one normal gene may not present any symptoms but can pass the gene to their offspring (carriers). Those carrying both genes develop Sickle Cell Anaemia. This test will determine how many sickle cell genes you have.
Gene Tested: HBB
Many prescribed drugs may not work for you. This can lead to a long course of ineffective treatment. This report can help your practitioner personalise your course of treatment by identifying the drugs that will benefit you the most.
+ Beta Blocker Efficiency
Beta blockers are a class of drugs used in the treatment of angina, heart failure, atrial fibrillation and high blood pressure. They act by lowering blood pressure and blood flow to the heart, thereby reducing the stress and pressure on the heart and preventing further damage. This test would determine the type of response you would have when using beta blocker treatments.
Gene Tested: GRK5
+ Beta Blockers and LVEF Response
Left Ventricular Ejection Fraction (LVEF) is the percentage of oxygenated blood being pumped around the body after each heartbeat and is a measurement to detect heart failure. This test determines your heart efficiency response following beta blocker treatment.
Gene Tested: ADRB1
+ Metoprolol metabolism
A type of beta-blocker used to treat angina, heart attack, atrial fibrillation and hypertension. A liver enzyme is responsible for breaking down 60% of this drug. This test would determine the levels of this enzyme in the body, which will indicate the recommended dose of Metoprolol to be given.
Gene Tested: CYP2D6
An anticoagulant drug used to prevent dangerous blood clots from forming. This test would determine your ability to metabolise Warfarin, helping you identify your optimal dose.
Genes Tested: CYP2C9 and VKORC1
An antiplatelet drug used to reduce the risk of heart disease and stroke. The drug works by preventing platelets from binding together that would otherwise lead to formation of blood clots. This test would determine your ability to metabolise Clopidrogrel.
Gene Tested: CYP2C19
+ Verapamil and QTC interval
Verapamil is used to treat hypertension, angina and arrhythmias (irregular heartbeats). This drug blocks calcium entry into blood vessels, causing them to widen such that blood pressure is reduced. Changes within a calcium gene can cause side effects when on Verapamil treatment. This test would determine your risk of developing cardiac problems whilst on Verapamil treatment.
Gene Tested: NOS1AP
+ Verapamil vs Atenolol
Verapamil (calcium channel blocker) and Atenolol (beta-blocker) are two classes of drugs used to treat high blood pressure and heart diseases. Our genes control how effectively we respond to one treatment over another. This test would allow you to identify which drug you are most likely to benefit from.
Gene Tested: CACNA1C
+ Simvastatin Uptake
Statins are a class of drugs that reduces the amount of cholesterol in your blood. A common side effect of statin use is myopathy (muscle disease). This test determines your risk of developing myopathy due to simvastatin use.
Gene Tested: SLCO1B1
+ Perindopril metabolism
Angiotensin Converting Enzyme (ACE) inhibitors are long-acting drugs used to treat hypertension. Alterations to the gene of this enzyme increases the chances of severe side effects whilst taking Perindopril. This test determines your risk of developing cardiac events while using Perindopril.
Gene Tested: AGTR1 and BDKRB1
+ Effects of caffeine on your heart
Caffeine is a natural substance found in coffee beans, tea and carbonated drinks. It has a direct effect on the heart by increasing heart rate. Although caffeine is good in small doses, large doses can cause uncontrollable increase in heart rate in some people. This test will determine the rate at which your body degrades caffeine.
Gene Tested: CYP1A2
Everyone processes food differently. We analyse how your genetics and lifestyle influence your metabolism with regards to cardiac related nutrients. This report guides you towards a lifestyle and diet that can optimise your health.
Triglycerides is a component of body fat present in the blood and is important for transporting fat to the liver. High levels of triglyceride is associated with an increased risk of heart disease.
Genes Tested: ANGPTL3, APOB, FADS1, GCKR, LPL, MLXIPL, NCAN, PLTP, TRIB1, XKR6, ZNF259
+ HDL Cholesterol
High-density lipoprotein (HDL) is known as the ‘good’ cholesterol as it removes excess and bad cholesterol from the blood. High level of HDL is associated with a lower risk of developing cardiovascular complications. This test determines your HDL levels and the risk of developing cardiovascular diseases.
Genes Tested: ABCA1, ANGPTL4, CETP, FADS1, GALNT2, HNF4A, KCTD10, LCAT, LIPC, LIPG, LPL, PLTP, TTC39B, ZNF259
+ LDL Cholesterol
Low-density lipoprotein (LDL) is known as ‘bad’ cholesterol because it can eventually build up fatty material in your blood vessels. As a result, the vessels become narrowed, and can lead to heart attack or stroke. This test will determine your LDL levels and the associated risk of developing cardiovascular complications.
Genes Tested: LDLR, MAFB, NCAN, PCSK9, ABCG8, APOB, CELSR2, HMGCR, HNF1A and Intergenic SNPs
+ Gene X
Carriers of Gene X have a 34% reduction in their risk of coronary artery disease, lower LDL and higher HDL levels. This test would determine if you have a copy of this gene and its associated health benefits.
Gene Tested: ASGR1
Approximately 90% of pulmonary emboli are caused by dislodged fragments from asymptomatic thrombotic blood clots. This test informs your clinician's decision making by identifying the heritable cause of thrombosis and the risk of developing a thrombotic event.
+ Estrogen Supplements
Hormone replacement therapy drugs and oral contraceptive pills contain estrogen, which is known to increase the risk of developing clotting disorders and thrombosis. This test will determine your genetic predisposition to developing thrombosis when taking drugs containing estrogen.
Genes Tested: Factor V Leiden and F2 Prothrombin
+ Venous Thrombosis
Venous thrombosis is a blood clot that forms within a vein. This clot can break off into the bloodstream and block an artery in the lungs, causing pulmonary embolism – a severe life-threatening condition.
Genes Tested: MTHFR, Prothrombin and Factor V Leiden
+ Folate and Homocysteine
Folate, also known as Folic acid, is a Vitamin B required by the body to make DNA. Folate cannot be made by the body and can only be obtained from your diet. Folate deficiency and increased levels of homocysteine is linked with increased risk of developing cardiovascular diseases. This test will determine your folate and homocysteine levels.
Gene Tested: MTHFR