Your genetics and lifestyle contribute towards your chances of developing certain cardiac conditions and exhibiting drug side-effects. Reveal how your heart health is predisposed by your DNA.
Our team of medics will analyse and interpret your results in light of your self reported health information and will give you a deep understanding of the status of your cardiac health.
Use comprehensive doctor's reviews to implement tailored lifestyle regimen that works for you, and make necessary interventions to protect and boost your cardiac health.
Take control of your future health and wellbeing. Pre-empt yourself from risks and be confident you are on the right path to a healthy heart. Health administers to peace of mind.
Atrial fibrillation is a heart condition characterised by an irregular and abnormally fast heart rate. Symptoms include dizziness, shortness of breath, tiredness or there may be no symptoms at all. Atrial fibrillation is a major cause of stroke
and coronary heart disease.
Gene Tested: PITX2
Coronary artery disease occurs when cholesterol and fatty substances are deposited along the artery walls, leading to atherosclerosis and compromising the blood supply to the heart. In turn, this can lead to a heart attack. Symptoms may not manifest until seconds before a heart attack is about to occur. The cause of coronary artery disease is strongly influenced by genetics and lifestyle, thus can be prevented.
Gene Tested: CDH13, HNF1A, MRAS, MTHFD1L, SEZ6L, SMAD3, CXCL12, MIA3, OR13GI, APC, CDKN2B and LPL
A myocardial infarction, also known as a heart attack, is a life-threatening event which occurs when the blood supply to the heart is blocked causing the heart to be starved of oxygen.
It is usually caused by a blood clot in the coronary artery. Symptoms may only occur seconds before a heart attack is about to happen. A myocardial infarction is the leading cause of death in the western world. Hypertrophic cardiomyopathy
is the most common genetic reason for sudden cardiac deaths in the young. The best way to prevent cardiac death in the young is to screen for it early.
Genes Tested: CXCL12, MIA3, OR13G1, PCSK9, PHACTR1, PRR4, SH2B3, WDR12 and Intergenic SNPs
1 in 4 adults in the UK have high blood pressure (above 140/90 mmHg). Symptoms of this condition can be dangerous if left unnoticed. If hypertension is not treated, the blood supply to the organs can become strained, leading to heart attacks, strokes, kidney problems, blindness and other organ dysfunctions.
Gene Tested: BCAT1 and PPARGC1A
Peripheral arterial disease occurs due to fat deposition in the arterial walls of the arteries supplying the legs. The progressive narrowing of the arteries reduces the blood flow and can cause symptoms of pain and discomfort whilst walking. Our test will determine the risk of your arteries becoming damaged.
Gene Tested: CHRNA3
Sickle Cell Anaemia is an inherited condition due to a faulty gene causing red blood cells to be disc shaped rather than round. The abnormal shape causes the cells to stick together and cause a blockage in blood vessels. Individuals with one sickle cell gene and one normal gene may not present any symptoms but can pass the gene to their offspring (carriers). Those carrying both genes will develop Sickle Cell Anaemia. This test will determine how many sickle cell genes you have and the risk of passing on the gene to the next generation.
Gene Tested: HBB
Type III hyperlipoproteinemia is a rare genetically inherited condition characterised by dysfunctional breakdown of lipids, causing a build-up of fatty materials in blood vessels. The fatty substances can build up in the arteries and obstruct blood flow, leading to coronary heart disease, myocardial infarction or peripheral vascular disease.
Gene Tested: APOE
Perindopril is a type of Angiotensin Converting Enzyme (ACE) inhibitor. ACE inhibitors are long-acting drugs used to treat hypertension. Alterations to the gene enzyme increases the chances of severe side effects. The test determines your risk of developing cardiac events while using perindopril.
Gene Tested: AGTR1 and BDKRB1
Beta-blockers are a drug class used in the treatment of angina, heart failure, atrial fibrillation and high blood pressure. The drug reduces the stress and pressure produced by the heart, reduces the blood pressure and decreases risk of cardiac damage. The test detects your receptor sensitivity to beta blockers, to ensure the drug will respond within your body.
Gene Tested: GRK5
Metoprolol is a type of beta-blocker that is used to treat angina, heart attacks, atrial fibrillation and hypertension. A liver enzyme is responsible for breaking down 60% of this drug. Testing this drug will determine your individual enzyme level in the body, which will indicate the precise recommended dose of Metoprolol to be given to you. Prescribing the correct dose can reduce the risk of side effects.
Gene Tested: CYP2D6
Verapamil is a drug in the class of calcium channel blockers (CCBs). It is used to treat hypertension, angina and arrhythmias (irregular heartbeats). By blocking calcium entry into blood vessels, the vessels dilate and reduce blood pressure. Genetic variabilities within the calcium gene can cause unfavourable reactions when on verapamil treatment. The test would determine your risk of developing cardiac problems whilst on verapamil treatment.
Gene Tested: NOS1AP
Atenolol (beta-blocker) and Verapamil (calcium channel blocker) are two classes of drugs used to treat high blood pressure and heart diseases. Our genes control how effectively we respond to one treatment over another. The test would show which drug is most effective for you.
Gene Tested: CACNA1C
Left Ventricular Ejection Fraction (LVEF) is the percentage of oxygenated blood being pumped around the body after each heartbeat. LVEF is particularly important in detecting the extent of heart failure. This test determines your heart efficiency response following beta-blocker treatment.
Gene Tested: CACNA1C and ADRB1
Warfarin is an anticoagulant drug used to prevent blood clots forming in the body. This test will determine your ability to metabolise warfarin and identifying the optimal dose for your body. A dose which is too high may cause excessive bleeding and a haemorrhage. A dose which is too low may cause a blood clot and a subsequent stroke. Therefore, identifying your ideal dose is vital.
Gene Tested: CYP2C9 and VKORC1
Clopidogrel is an antiplatelet drug used to reduce the risk of heart disease and stroke. The drug works by preventing platelets from binding together that would otherwise cause blood clots. This test will determine your ability to metabolise clopidogrel, allowing a precise drug dose to be given.
Gene Tested: CYP2C19
Statins are a class of drug that reduce the amount of cholesterol in your blood. A common side effect of statin use is myopathy (muscle disease). The test determines your risk of developing myopathy due to statin use.
Gene Tested: SLCO1B1
Triglycerides are a component of body fat present in the blood. They have a vital role in the transportation of body fat from the arteries to the liver. High level of triglycerides are associated with an increased risk of heart disease. By detecting the triglyceride level, you can prevent heart complications.
Genes Tested: ANGPTL3, APOB, FADS1, GCKR, LPL, MLXIPL, NCAN, PLTP, TRIB1, XKR6, ZNF259
High-Density Lipoprotein (HDL) is known as ‘good’ cholesterol as it removes cholesterol from the blood vessels and transports it to the liver. High levels of HDL are associated with a lower risk of developing cardiovascular complications. The test determines your HDL levels and the risk of developing cardiovascular diseases.
Genes Tested: ABCA1, ANGPTL4, CETP, FADS1, GALNT2, HNF4A, KCTD10, LCAT, LIPC, LIPG, LPL, PLTP, TTC39B, ZNF259
Low-Density Lipoprotein (LDL) is known as ‘bad’ cholesterol as it transports cholesterol from the liver to the blood vessels. Gradually, the vessels become narrowed and can lead to heart attack or stroke. This test will determine your LDL levels and the associated risk of developing cardiovascular complications.
Genes Tested: LDLR, MAFB, NCAN, PCSK9, ABCG8, APOB, CELSR2, HMGCR, HNF1A and Intergenic SNPs
Gene X has protective effects on cardiac health. Carriers of Gene X have a 34% reduction in their risk of coronary artery disease, lower Low-Density Lipoprotein and higher High-Density Lipoprotein levels. The test will determine whether you possess a copy of this gene and can benefit from the increased health outcomes.
Genes Tested: ASGR1
Venous thrombosis is a disease whereby a blood clot forms within a vein and stops the flow of blood. The clot can break off into the bloodstream and get trapped in a smaller artery in the lungs or brain. Blocking an artery in the lungs or brain can cause life-threatening conditions, a pulmonary embolism or a stroke. These conditions can be prevented if a venous thrombosis is detected.
Gene Tested: MTHFR, Prothrombin and Factor V Leiden
Folate, also known as Folic acid or vitamin B9, is a B vitamin required by the body to make DNA. Folate cannot be made by the body so must be obtained by diet. Homocysteine is an amino acid, which in high levels can cause arterial damage and blood clots in the body. Folate deficiency and increased levels of homocysteine is linked with increased risk of developing cardiovascular disease. The test will determine your specific folate and homocysteine levels, to allow you to make dietary changes.
Genes Tested: MTHFR
Hormone replacement therapy drugs and combined oral contraceptive pills contain oestrogen, which is known to increase the risk of developing clotting disorders and thrombosis. The test would determine your genetic predisposition to developing thrombosis when taking drugs containing oestrogen.
Gene Tested: Factor V Leiden and F2 Prothrombin
High cholesterol, strokes, heart attacks or diabetes can pass down through your family, If you have a family history of heart disease, you may have a chance of developing similar conditions in the future.
Smoking, excess weight, stress and binge drinking can put you at a higher chance of developing heart disease. Heart DNA Test will identify how your physiology and lifestyle can be altered for a healthier heart.
Not all heart problems come with obvious symptoms. If sometimes you experience shortness of breath, pain in the chest, tiredness and palpitations, take the test and understand your risks.
Anxiety and worry may magnify when administered drugs do not work. Heart DNA Test will reassure you by letting you know if your current treatment is right for you, and how you can optimise it.
Summary report will be available to download and print. Follow up with your doctor or book an appointment with one of our partner doctors via your portal.
Your results will be available on the web pages in your account. All DNA glitches will be shown with explanation and further in-depth reading.
Qualified specialists will provide a medical review based on your genetic makeup and health profile.
Nutritional advice and dietary changes.
Lifestyle and healthy living advice.
Caffeine tolerance and metabolism.
Practical advice to reduce cholesterol.
Optimisation and personalisation of an existing treatment plan.
Symptoms that may indicate onset of heart disease.
Identify risk factors that cause blood clots.
Signpost for further investigations.
It's been such an interesting experience. You think DNA testing would be quite complicated, but in fact these guys have made it so simple. Anyone can do it!
If your results show several worrying signs or areas of potential risk, we would advise that you get a full heart screen. Your private medical cover should pay for this, depending on who you are with. If you use Heart DNA Test from us, you receive a significant discount off the normal cost. Plus, you will get access to our network of world-class experts should you require further investigation or treatment.
No. It is pain and blood free. You simply swab the inner side of your cheek, that’s it.
To ensure the efficacy and accuracy of our service, we have partnered with ISO accredited labs that adhere to high standards of quality. Our gene panel list is assayed through a genotyping technology that utilises competitive allele-specific microarray technology, which enables highly accurate bi-allelic scoring of SNPs (99.8% accurate) and indels (insertions and deletions) at specific loci across a wide range of genomic DNA samples (SNP & indel assay conversion rate 90%), thereby limiting the risk of false-positive and false-negative results.
Once the results are processed, they are then reviewed by our specialist partners, along with your provided health profile, in order to provide your with comprehensive context on your results with action plans on what you can do next.