Uncover your Genes and live your future health well.

Heart DNA Test is a proactive way to manage your heart health and have a long worry-free happy life.

Get your Heart DNA tested today

Heart DNA Test will identify DNA glitches that can increase (or lower) your cardiovascular risks, impact your response to heart medications, alter your chances of developing a blood clot or having abnormal cholesterol levels.

What can this test do for you?

Discover

Your genetics and lifestyle contribute towards your chances of developing certain cardiac conditions and exhibitng drug side-effects. Reveal how your heart health is predisposed by your DNA.

Acquire

Our team of medics will analyse and interpret your results in light of your self reported health information and will give you a deep understanding on the status of your cardiac health.

Take action

Use comprehensive doctors’ reviews to implement a treatment regimen that works for you and make necessary interventions to protect and uplift your cardiac health.

Control

Take control of your future health and wellbeing. Pre-empt yourself from risks and be confident you are on the right path to a healthy heart. Health administers to peace of mind.

Why take Heart DNA Test?

Heredity

High cholesterol, strokes, heart attacks or diabetes can pass down through your family, If you have a family history of a heart disease you may have a chance of developing similar conditions.

Lifestyle

Smoking, excess weight, stress and binge drinking can put you at a higher chance of developing a heart disease. Heart DNA Test will identify how your physiology and lifestyle can be altered for a healthier heart.

Symptoms

Not all heart problems come with obvious symptoms. If sometimes you experience shortness of breath, pain in the chest, tiredness and palpitations take the test and understand your risks.

Living with a condition

Anxiety and worry may magnify when administered drugs do not work for you. Heart DNA Test will help you rest assured by letting you know if your current treatment is right for you.

What the report looks like?

26 reports covering 4 main aspects focused on your heart health.

Report Summary

Summary report will be available to download and print. Follow up with your doctor or book an appointment with one of our partner doctors via your portal.

Genetic information

Your results will be available on web pages from your account, all DNA glitches will be shown with explanation and further in-depth reading.

Tailored Action Plan

Specialists will provide medical review based on your genetic makeup and health profile.

What does Heart DNA test for?

Cardiovascular Risk analysis

We screen for genetic predispositions linked to cardiovascular diseases and identify any associated risks that might be affecting your cardiac health and wellness. Your cardiologist review will give you detailed advice on how to optimise your cardiac health and wellness.

Atrial Fibrillation

Atrial fibrillation is a heart condition characterised by irregular and abnormally fast heart rate. Symptoms include dizziness, shortness of breath, tiredness or no symptoms at all. Atrial fibrillation is a major cause of stroke and coronary heart disease..

Gene Tested: PITX2

Coronary Artery Disease

Coronary artery disease occurs when cholesterol and fatty substances are deposited along the artery walls, leading to atherosclerosis and compromising the blood supply to the heart. in turn, this can lead to a heart attack. Symptoms may not manifest until seconds before a heart attack is about to occur. The cause of coronary artery disease is strongly influenced by genetics and lifestyle, thus can be prevented.

Gene Tested: CDH13, HNF1A, MRAS, MTHFD1L, SEZ6L, SMAD3, CXCL12, MIA3, OR13GI, APC, CDKN2B and LPL

Myocardial Infarction (Heart Attack)

A myocardial infarction, also known as a heart attack, is a life-threatening event which occurs when the blood supply to the heart is blocked causing the heart to be starved of oxygen. It is usually caused by a blood clot in the coronary artery. Symptoms may only occurs seconds before a heart attack is about to occur. A myocardial infarction is the leading cause of death in the western world. Hypertrophic cardiomyopathy is the most common genetic reason for sudden cardiac deaths in the young. The best way to prevent cardiac death in the young is to screen for it early.

Genes Tested: CXCL12, MIA3, OR13G1, PCSK9, PHACTR1, PRR4, SH2B3, WDR12 and Intergenic SNPs

Hypertension

1 in 4 adults in the UK have high blood pressure (above 140/90 mmHg). Symptoms of this condition can dangerously be left unnoticed. If hypertension is not treated, blood vessels can strain the blood supply to organs, leading to heart attacks, strokes, kidney problems, blindness and other organ dysfunction.

Gene Tested: BCAT1 and PPARGC1A

Peripheral Arterial Disease

Peripheral arterial disease occurs due to fat deposition in the arterial walls of the arteries supplying the legs. The progressive narrowing of the arteries reduces the blood flow and can cause symptoms of pain and discomfort whilst walking.  Our test will determine the risk of your arteries becoming damaged.

Gene Tested: CHRNA3

Sickle Cell Anaemia

Sickle Cell Anaemia is an inherited condition due to a faulty gene causing red blood cells to be disc shaped rather than round. The abnormal shape causes the cells to stack together and cause a blockage in blood vessels. Individuals with one sickle cell gene and one normal gene may not present any symptoms but can pass the gene to their offspring (carriers). Those carrying both genes will develop Sickle Cell Anaemia. This test will determine how many sickle cell genes you have and the risk of passing on the gene to the next generation.

Gene Tested: HBB

Type III Hyperlipoproteinemia

Type III hyperlipoproteinemia is a rare genetically inherited condition characterised by dysfunctional breakdown of lipids, causing build-up of fatty materials in blood vessels. The fatty substances can build up in the arteries and obstruct blood flow, leading to coronary heart disease, myocardial infarction or peripheral vascular disease.

Gene Tested: APOE

Drug Response

Many prescribed drugs may not work for you. This can lead to a long course of ineffective treatment. This test can help your practitioner personalise your course of treatment by identifying the drugs that will benefit you the most.

ACE inhibitors

Perindopril is a type of Angiotensin Converting Enzyme (ACE) inhibitor, which are long-acting drugs used to treat hypertension. Alterations to the gene enzyme increases the chances of severe side effects. The test determines your risk of developing cardiac events while using perindopril.

Gene Tested: AGTR1 and BDKRB1

Beta-blockers

Beta-blockers are a drug class used in the treatment of angina, heart failure, atrial fibrillation and high blood pressure. The drug reduces the stress and pressure produced by the heart, reduces the blood pressure and decreases risk of cardiac damage. The test detects your receptor sensitivity to beta blockers, to ensure the drug will respond within your body.

Gene Tested: GRK5

Metoprolol

Metoprolol is a type of beta-blocker that is used to treat angina, heart attack, atrial fibrillation and hypertension. A liver enzyme is responsible for breaking down 60% of this drug. Testing this drug would determine your individual enzyme level in the body, which will indicate the precise recommended dose of Metoprolol to be given to you. Prescribing the correct dose can reduce risk of side effects.

Gene Tested: CYP2D6

Calcium Channel Blockers

Verapamil is a drug in the class of calcium channel blockers (CCB). It is used to treat hypertension, angina and arrhythmias (irregular heartbeats). By blocking calcium entry into blood vessels, the vessels dilate and reduce blood pressure. Genetic variabilities within calcium gene can cause unfavourable reactions when on verapamil treatment. The test would determine your risk of developing cardiac problems whilst on verapamil treatment.

Gene Tested: NOS1AP

Beta-blockers V Calcium Channel Blockers

Atenolol (beta-blocker) and Verapamil (calcium channel blocker) are two classes of drugs used to treat high blood pressure and heart diseases. Our genes control how effectively we respond to one treatment over another. The test would show which drug is most effective for you.

Gene Tested: CACNA1C

Beta-blockers and Left Ventricular Ejection Fraction Response

Left Ventricular Ejection Fraction (LVEF) is the percentage of oxygenated blood being pumped around the body after each heartbeat. LVEF is particularly important in detection the extent of heart failure.  This test determines your heart efficiency response following beta-blocker treatment.Gene Tested: ADRB1
Gene Tested: CACNA1C

Warfarin

Warfarin is an anticoagulant drug used to prevent blood clots forming in the body. This test would determine your ability to metabolise warfarin, producing the dose optimal for your body. A dose too high may cause excessive bleeding and a haemorrhage. A dose too low may cause a blood clot and subsequent stroke. Therefore, identifying your ideal dose is vital.

Gene Tested: CYP2C9 and VKORC1

Clopidogrel

Clopidogrel is an antiplatelet drug used to reduce the risk of heart disease and stroke. The drug works by preventing platelets from binding together that would otherwise cause a blood clots. This test would determine your ability to metabolise clopidogrel, allowing a precise drug dose to be given.

Gene Tested: CYP2C19

Statins

Statins are a class of drug that reduce the amount of cholesterol in your blood. A common side effect of statin use is myopathy (muscle disease). The test determines your risk of developing myopathy due to statin use.

Gene Tested: SLCO1B1

Lipids metabolism

Everyone processes food differently. We analyse how your genetics and lifestyle impact your metabolism in relation to cardiac related nutrients. This test guides you towards a lifestyle and diet that can optimise your health and maintain healthy lipids levels in your body.

Triglycerides

Triglycerides are a component of body fat present in the blood. It has an important role in transportation of body fat from the arteries to the liver. High levels of triglyceride is associated with an increased risk of heart disease. By detecting the triglyceride level, you can prevent heart complications.

Genes Tested: ANGPTL3, APOB, FADS1, GCKR, LPL, MLXIPL, NCAN, PLTP, TRIB1, XKR6, ZNF259

High-Density Lipoprotein Cholesterol

High-Density Lipoprotein (HDL) is known as ‘good’ cholesterol as it removes cholesterol from the blood vessels and transports to the liver. High level of HDL are associated with a lower risk of developing cardiovascular complications. The test determines your HDL levels and the risk of developing cardiovascular diseases.

Genes Tested: ABCA1, ANGPTL4, CETP, FADS1, GALNT2, HNF4A, KCTD10, LCAT, LIPC, LIPG, LPL, PLTP, TTC39B, ZNF259

Low-Density Lipoprotein Cholesterol

Low-Density Lipoprotein (LDL) is known as ‘bad’ cholesterol as it transports cholesterol from the liver to the blood vessels. Gradually, the vessels become narrowed and can lead to heart attack or stroke. This test will determine your LDL levels and the associated risk of developing cardiovascular complications.

Genes Tested: LDLR, MAFB, NCAN, PCSK9, ABCG8, APOB, CELSR2, HMGCR, HNF1A and Intergenic SNPs

Gene X (Cardio protective glitch)

Gene X has protective effects towards cardiac health. Carriers of Gene X have a 34% reduction in their risk of coronary artery disease, lower Low-Density Lipoprotein and higher High-Density Lipoprotein levels. The test will determine whether you possess a copy of this gene and can benefit from the increased health outcomes.

Genes Tested: ASGR1

Thrombophilia
(Woman Wellness)

Approximately 90% of pulmonary emboli are caused by dislodged fragments from asymptomatic thrombotic blood clots. This test informs your clinician's decision making by identifying the heritable cause of thrombosis and the risk of developing a thrombotic event.

Venous Thrombosis

Venous thrombosis is a disease whereby a blood clot forms within a vein and stops the flow of blood. The clot can break off into the bloodstream and get trapped in a smaller artery in the lungs or brain. Blocking an artery in the lungs or brain can cause life-threatening conditions, a pulmonary embolism or a stroke. These conditions can be prevented if a venous thrombosis is detected.

Gene Tested: MTHFR, Prothrombin and Factor V Leiden

Folate and homocysteine

Folate, also known as Folic acid, is a Vitamin B required by the body to make DNA. Folate cannot made by the body so must be obtained by diet. Homocysteine is an amino acid, which in high levels can cause arterial damage and blood clots in the body. Folate deficiency and increased levels of homocysteine is linked with increased risk of developing cardiovascular disease. The test will determine your specific folate and homocysteine levels, to allow you to make dietary changes.

Genes Tested: MTHFR

Estrogen Supplements risk

Hormone replacement therapy drugs and combined oral contraceptive pills contain estrogen, which is known to increase the risk of developing clotting disorders and thrombosis. The test would determine your genetic predisposition to developing thrombosis when taking drugs containing estrogen.

Gene Tested: Factor V Leiden and F2 Prothrombin

Practical advice

Nutritional advice and dietary changes

Lifestyle and healthy living advice

Caffeine tolerance and metabolism

Practical advice to reduce cholesterol

Environmental factors do influence your genes and how your DNA is expressed. Hence, implementing targeted behaviour changes into your diet and lifestyle can influence your genetic risk.

Medical review

Optimisation and personalisation of an existing treatment plan.

Symptoms that may indicate onset of heart disease

Identify risk factors that cause blood clots

Signpost for further investigations.

Your tailored action plan

It's been such an interesting experience. You think DNA testing would be quite complicated, but in fact these guys have made it so simple.. Anyone can do it!

Steve S.
Heart DNA test patient
United Kingdom

Get the Right advice

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Will I need to go for a full heart screen?

If your results show several worrying signs or areas of potential risk, we would advise that you get a full heart screen. Your private medical cover should pay for this, depending on who you are with. If you use Heart DNA Test from us, you receive a significant discount off the normal cost. Plus you get will get access to our network of world-class experts should you require further investigation or treatment.