Heart DNA Test to Personalise Your Cardiac Medical Care.

Heart DNA Test is a proactive way to personalise your cardiac health and have a worry-free life. The test will help you be more certain and get better answers regarding your Cardiac health, treatment regimen, Lipid metabolism and risks of blood clots.

Heart DNA test kit

£129

£129

What's included in the Heart DNA Test?

Your test will have..

24 point detailed report covering 4 main aspects, all focused on your heart and cardiovascular health.

Heart DNA Test summary report

Medical Assessment

Qualified specialists will provide a medical review based on your genetic makeup and health profile.

Detailed reports

Your results will be available on the dashboard in your online portal. All DNA glitches will be shown with explanation and further in-depth reading.

Summary Report infographic

Summary report will be available to download and print. Follow up with your doctor or book an appointment with one of our partner doctors via your portal.

What will your DNA say?

The Heart DNA Test will identify glitches in your DNA which increase (or decrease) your chance of developing cardiovascular risks, your response to heart medications, your chances of developing a blood clot or having abnormal cholesterol levels. A full medical review and assessment by a medical practitioner is included.

Cardiovascular Risk Analysis

We screen for genetic predispositions linked to cardiovascular diseases and identify any associated risks that might be affecting your cardiac health and wellness. Your cardiologist review will give you detailed advice on how to optimise your cardiac health and wellness.

Atrial Fibrillation

Atrial fibrillation is a heart condition characterised by an irregular and abnormally fast heart rate. Symptoms include dizziness, shortness of breath, tiredness or there may be no symptoms at all. Atrial fibrillation is a major cause of stroke and coronary heart disease.

Gene Tested: PITX2

Coronary Artery Disease

Coronary artery disease occurs when cholesterol and fatty substances are deposited along the artery walls, leading to atherosclerosis and compromising the blood supply to the heart. In turn, this can lead to a heart attack. Symptoms may not manifest until seconds before a heart attack is about to occur. The cause of coronary artery disease is strongly influenced by genetics and lifestyle, thus can be prevented.

Gene Tested: CDH13, HNF1A, MRAS, MTHFD1L, SEZ6L, SMAD3, CXCL12, MIA3, OR13GI, APC, CDKN2B and LPL

Myocardial Infarction (Heart Attack)

A myocardial infarction, also known as a heart attack, is a life-threatening event which occurs when the blood supply to the heart is blocked causing the heart to be starved of oxygen.
It is usually caused by a blood clot in the coronary artery. Symptoms may only occur seconds before a heart attack is about to happen. A myocardial infarction is the leading cause of death in the western world. Hypertrophic cardiomyopathy is the most common genetic reason for sudden cardiac deaths in the young. The best way to prevent cardiac death in the young is to screen for it early.

Genes Tested: CXCL12, MIA3, OR13G1, PCSK9, PHACTR1, PRR4, SH2B3, WDR12 and Intergenic SNPs

Hypertension

One in four adults in the UK have high blood pressure (above 140/90 mmHg). Symptoms of this condition can be dangerous if left unnoticed. If hypertension is not treated, the blood supply to the organs can become strained, leading to heart attacks, strokes, kidney problems, blindness and other organ dysfunctions.

Gene Tested: BCAT1 and PPARGC1A

Peripheral Arterial Disease

Peripheral arterial disease occurs due to fat deposition in the arterial walls of the arteries supplying the legs. The progressive narrowing of the arteries reduces the blood flow and can cause symptoms of pain and discomfort whilst walking.  Our test will determine the risk of your arteries becoming damaged.

Gene Tested: CHRNA3

Sickle Cell Anaemia

Sickle Cell Anaemia is an inherited condition due to a faulty gene causing red blood cells to be disc shaped rather than round. The abnormal shape causes the cells to stick together and cause a blockage in blood vessels. Individuals with one sickle cell gene and one normal gene may not present any symptoms but can pass the gene to their offspring (carriers). Those carrying both genes will develop Sickle Cell Anaemia. This test will determine how many sickle cell genes you have and the risk of passing on the gene to the next generation.

Gene Tested: HBB

Type III Hyperlipoproteinemia

Type III hyperlipoproteinemia is a rare genetically inherited condition characterised by dysfunctional breakdown of lipids, causing a build-up of fatty materials in blood vessels. The fatty substances can build up in the arteries and obstruct blood flow, leading to coronary heart disease, myocardial infarction or peripheral vascular disease.

Gene Tested: APOE

Heart Medications Response

Many prescribed drugs may not work for you. This can lead to a long course of ineffective treatment. This test can help your practitioner personalise your course of treatment by identifying the drugs that will benefit you the most.

ACE inhibitors

Angiotensin Converting Enzyme (ACE) inhibitors are long-acting drugs used to treat hypertension. Alterations to the gene enzyme increase the chances of severe side effects. The test determines your risk of developing cardiac events while using this class of drugs.

Gene Tested: AGTR1 and BDKRB1

Beta-blockers sensitivity

Beta-blockers are a drug class used in the treatment of angina, heart failure, atrial fibrillation and high blood pressure. The drug reduces the stress and pressure produced by the heart, reduces the blood pressure and decreases risk of cardiac damage. The test detects your receptor sensitivity to beta blockers, to ensure the drug will respond within your body.

Gene Tested: GRK5

Beta-Blockers metabolism

Beta-blocker are used to treat angina, heart attacks, atrial fibrillation and hypertension. A liver enzyme is responsible for breaking down sixty percent of the drug. Testing this drug's metabolism will determine your individual enzyme level in the body, which will indicate the precise recommended dose to be given to you. Prescribing the correct dose can reduce the risk of side effects.

Gene Tested: CYP2D6

Calcium Channel Blockers

Calcium channel blockers (CCBs) are used to treat hypertension, angina and arrhythmias (irregular heartbeats). By blocking calcium entry into blood vessels, the vessels dilate and reduce blood pressure. Genetic variabilities within the calcium gene can cause unfavourable reactions when on treatment. The test would determine your risk of developing cardiac problems whilst on this medication.

Gene Tested: NOS1AP

Beta-blockers V Calcium Channel Blockers

Beta-blockers and Calcium channel blockers are two classes of drugs used to treat high blood pressure and heart diseases. Our genes control how effectively we respond to one treatment over another. The test would show which drug is most effective for you.

Gene Tested: CACNA1C

Beta-blockers and Left Ventricular Ejection Fraction Response

Left Ventricular Ejection Fraction (LVEF) is the percentage of oxygenated blood being pumped around the body after each heartbeat. LVEF is particularly important in detecting the extent of heart failure.  This test determines your heart efficiency response following beta-blocker treatment.

Gene Tested: CACNA1C and ADRB1

Anticoagulants sensitivity

Anticoagulant drugs are used to prevent blood clots forming in the body. This test will determine your ability to metabolise anticoagulants and identifying the optimal dose for your body. A dose which is too high may cause excessive bleeding and a haemorrhage. A dose which is too low may cause a blood clot and a subsequent stroke. Therefore, identifying your ideal dose is vital.

Gene Tested: CYP2C9 and VKORC1

Antiplatelets metabolism

Anti-platelet drugs are used to reduce the risk of heart disease and stroke. The drug works by preventing platelets from binding together that would otherwise cause blood clots. This test will determine your metabolic ability to the drug, allowing a precise dose to be given.

Gene Tested: CYP2C19

Lipid lowering drugs

A class of drugs is used to reduce the amount of cholesterol in your blood. A common side effect of these lipid lowering drugs is myopathy (muscle disease). The test determines your risk of developing myopathy due to drug usage.

Gene Tested: SLCO1B1

Fats (Lipid) Metabolism

Everyone processes food differently. We analyse how your genetics and lifestyle impact your metabolism in relation to cardiac related nutrients. This test guides you towards a lifestyle and diet that can optimise your health and maintain healthy lipid levels in your body.

Triglycerides

Triglycerides are a component of body fat present in the blood. They have a vital role in the transportation of body fat from the arteries to the liver. High level of triglycerides are associated with an increased risk of heart disease. By detecting the triglyceride level, you can prevent heart complications.

Genes Tested: ANGPTL3, APOB, FADS1, GCKR, LPL, MLXIPL, NCAN, PLTP, TRIB1, XKR6, ZNF259

High-Density Lipoprotein Cholesterol

High-Density Lipoprotein (HDL) is known as ‘good’ cholesterol as it removes 'bad' cholesterol from the blood vessels and transports it to the liver. High levels of HDL are associated with a lower risk of developing cardiovascular complications. The test determines your HDL levels and the risk of developing cardiovascular diseases.

Genes Tested: ABCA1, ANGPTL4, CETP, FADS1, GALNT2, HNF4A, KCTD10, LCAT, LIPC, LIPG, LPL, PLTP, TTC39B, ZNF259

Low-Density Lipoprotein Cholesterol

Low-Density Lipoprotein (LDL) is known as ‘bad’ cholesterol as it transports cholesterol from the liver to the blood vessels. Gradually, the vessels become narrowed and can lead to heart attacks or strokes. This test will determine your LDL levels and the associated risk of developing cardiovascular complications.

Genes Tested: LDLR, MAFB, NCAN, PCSK9, ABCG8, APOB, CELSR2, HMGCR, HNF1A and Intergenic SNPs

Blood Clot Risk Analysis

Approximately 90% of pulmonary emboli are caused by dislodged fragments from asymptomatic thrombotic blood clots. This test informs your clinician's decision making by identifying the heritable cause of thrombosis and the risk of developing a thrombotic event.

Venous Thrombosis

Venous thrombosis is a disease whereby a blood clot forms within a vein and stops the flow of blood. The clot can break off into the bloodstream and get trapped in a smaller artery in the lungs or brain. Blocking an artery in the lungs or brain can cause life-threatening conditions, a pulmonary embolism or a stroke. These conditions can be prevented if a venous thrombosis is detected.

Gene Tested: MTHFR, Prothrombin and Factor V Leiden

Folate and Homocysteine

Folate, also known as Folic acid or vitamin B9, is a B vitamin required by the body to make DNA. Folate cannot be made by the body so must be obtained by diet. Homocysteine is an amino acid, which in high levels can cause arterial damage and blood clots in the body. Folate deficiency and increased levels of homocysteine is linked with increased risk of developing cardiovascular disease. The test will determine your specific folate and homocysteine levels, to allow you to make dietary changes.

Genes Tested: MTHFR

Oestrogen Supplements Risk

Hormone replacement therapy drugs and combined oral contraceptive pills contain oestrogen, which is known to increase the risk of developing clotting disorders and thrombosis. The test would determine your genetic predisposition to developing thrombosis when taking drugs containing oestrogen.

Gene Tested: Factor V Leiden and F2 Prothrombin

It's been such an interesting experience. You think DNA testing would be quite complicated, but in fact these guys have made it so simple. Anyone can do it!

Steve S.
United Kingdom

"Our genetic makeup is beyond our control, yet is a critical part of determining the risk of many of these diseases, as well as the response to treatment. This is where genetic analyses such as the Heart DNA test comes in"

Professor Sir John Cunningham

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